2010

Creemers, H.E., Dijkstra, J.K., Vollebergh, W.A.M., Ormel, J., Verhulst, F.C., Huizink A.C. Predicting lifetime and regular cannabis use during adolescence; the roles of temperament and peer substance use - The TRAILS study. Addiction 2010, april;105(4) 699-708

Aims: The aim of the present study was to determine the mediating role of affiliation with cannabis-using peers in the pathways from various dimensions of temperament to lifetime cannabis use, and to determine if these associations also contributed to the development of regular cannabis use.
Methods: Objectives were studied using data from 1300 participants of the Tracking Adolescents’ Individual Lives Survey (TRAILS), a large, general population study of Dutch adolescents. We used parent-reports on the Early Adolescent Temperament Questionnaire to assess the dimensions high-intensity pleasure, shyness, fearfulness, frustration, and effortful control at age 10-12. By means of self-reports, lifetime and regular cannabis use were determined at age 15-18, and proportion of substance-using peers was determined at ages 12-15 and 15-18. Models were adjusted for age, sex, intelligence, and parental cannabis use.
Results: High-intensity pleasure (OR=1.09, 95%CI=1.05-1.13) and effortful control (OR=0.92, 95%CI=0.89-0.96) affected the risk for lifetime cannabis use through their influence on affiliation with cannabis-using peers. Shyness affected this risk independent from peer cannabis use. Only the pathway from effortful control was additionally associated with the development of regular cannabis use (OR=0.93, 95%CI=0.89-0.98).
Conclusions: Peer cannabis use and, to a lesser extent, certain temperamental characteristics affect an adolescent’s risk of cannabis use, and should be considered in prevention programs. We recommend future research to focus on factors that potentially modify the association between temperament, affiliation with cannabis-using peers and cannabis use.

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Korhonen T, Prince A., Reijneveld SA, Ormel J., Verhulst FC, Huizink AC (2010). Externalizing Behavior Problems and Cigarette Smoking as Predictors of Cannabis Use: The TRAILS Study. J. Am. Acad. Child Adolesc. Psychiatry, ;49(1):61-69.

Objective: To examine externalizing behavior problems and cigarette smoking as predictors Of Subsequent cannabis use. Method: Dutch adolescents (N = 1,606; 854 girls and 752 boys) from the TRacking Adolescents' Individual Lives Survey (TRAILS) ongoing longitudinal study were examined at baseline (ages 10-12 [T1]) and at two follow-up assessments (ages 12-15 [T2] and 15-18 [T3]). The analysis focused on DSM-IV externalizing behavior (conduct, attention deficit hyperactivity, and oppositional) problems at T1, assessed by the Youth Self Report and the Child Behavior Check List, on self-reported ever smoking at T2, and on cannabis use at T3. Results: All associations of parent-rated externalizing behavior problems with cannabis were mediated by earlier smoking. Considering self-reported problems, none of these associations with cannabis were mediated by smoking, except the influence of self-reported conduct problems in girls. Interestingly, even after adjusting for externalizing problems, earlier smoking independently and consistently predicted cannabis use. The adjusted odds ratios for smoking varied in boys from 4.8 to 5.2 (ever) from 10 to 12 (daily) and from 22 to 23 (early-onset) whereas in girls from 4.9 to 5.0, 5.6 to 6.1, and 27 to 28, respectively (p <.001 for all). Conclusions: Our findings challenge the view that externalizing behavior problems directly predict cannabis initiation. Such associations were inconsistent across informants and sexes and were often mediated by earlier smoking. Early smoking onset is a powerful predictor of later cannabis initiation independent of preceding externalizing behavior problems. Although externalizing behavior problems are important as a starting point for substance use trajectories, early-onset smoking Should be identified as an important marker of cannabis use risk.

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