Van der Knaap L.J., Oldehinkel A.J., Verhulst F.C., van Oort F.V.A., Riese H. › Trails

TRAILS

Glucocorticoid receptor gene methylation and HPA-axis regulation in adolescents. The TRAILS study

Authors: Van der Knaap L.J., Oldehinkel A.J., Verhulst F.C., van Oort F.V.A., Riese H.

Highlights

  • We investigated the association between HPA-axis regulation and NR3C1 methylation.
  • HPA-axis regulation was operationalized as stress response activation and recovery.
  • NR3C1 methylation was not associated with activation of the stress response.
  • NR3C1 methylation was associated with a slower recovery of the stress response.
  • NR3C1 methylation possibly impairs negative feedback of the HPA-axis.
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