Markers of stress and inflammation as potential mediators of the relationship between exercise and depressive symptoms: Findings from the TRAILS study
The hypothalamic-pituitary-adrenal axis, autonomic nervous system, and immune system have been proposed to underlie the antidepressant effect of exercise. Using a population sample of 715 adolescents, we examined whether pathways from exercise to affective and somatic symptoms of depression were mediated by these putative mechanisms. Exercise (hours/week) and depressive symptoms were assessed at age 13.5 (Â±â€‰0.5) and 16.1 (Â±â€‰0.6). Cortisol and heart rate responses to a standardized social stress test and C-reactive protein levels were measured at age 16. Exercise was prospectively and inversely related to affective (Bâ€‰=â€‰-0.16, 95% CIâ€‰=â€‰-0.30 to -0.03) but not somatic symptoms (Bâ€‰=â€‰-0.04, 95% CIâ€‰=â€‰-0.21 to 0.13). Heart rate during social stress partially mediated this relationship (Bâ€‰=â€‰-0.03, 95% CIâ€‰=â€‰-0.07 to -0.01). No other mediating effects were found. Hence, the autonomic stress system may play a role in the relationship between exercise and depressive symptoms.
© 2014 Society for Psychophysiological Research.